Noble's research focuses on using computer models of biological organs and organ systems to interpret function from the molecular level to the whole organism. Together with international collaborators, his team has used supercomputers to create the first virtual organ, the virtual heart. As secretary-general of the International Union of Physiological Sciences 1993–2001, he played a major role in launching the Physiome Project, an international project to use computer simulations to create the quantitative physiological models necessary to interpret the genome, and he was elected president of the IUPS at its world congress in Kyoto in 2009. Denis Noble is also a philosopher of biology. He is the author of The Music of Life and Dance to the Tune of Life, popular books challenging gene-centric interpretations of modern biology. He sees genes as simply templates for making the proteins we need. Genes are controlled by us, and that includes their random variations. He is Emeritus Professor at the University of Oxford.